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J Gastroenterol Hepatol. 2001 Sep; 25(9):1360-7. Deletion of the ferrochelatase gene in a patient with protoporphyria. 2004 Aug 01; 173(3):1561-70. 2002 Sep; 132(3):441-9. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2007 Dec; 52(12):3404-15. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. 2012 Nov; 143(5):1330-1340.e1. Researchers can. Transplantation. 2011 Oct; 89(10):997-1013. 1994 Sep; 17(3):410-2. Clin Gastroenterol Hepatol. J Gastroenterol Hepatol. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. J Gastroenterol. Biofactors. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. 2002 Jul; 283(1):G204-11. 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Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. 1994 Sep; 3(9):1695-7. 2010 Feb; 16(2):181-90. 2006 May; 130(6):1886-900. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. 2019 Feb; 3(2):180-192. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Arch Clin Biomed Res. 2017 Jun 16; 7:314-323. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Studies with human cultured skin fibroblasts. 2013 Dec; 11(12):1636-45.e1-3. 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Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Hepatology. J Hepatobiliary Pancreat Sci. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. 1996 Sep; 24(3):670-6. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. 2007 Dec; 47(6):834-43. Nat Med. Stem Cells Cloning. Cancer Res. 2014 Dec; 26(12):1802-11. Infect Immun. 2005 Jun 10; 280(23):21763-72. 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Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. 2010 Oct; 52(4):1420-30. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. 2001 Jan; 33(1):81-90. Aging Ment Health. 1996 Sep; 50(3):656-61. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Heterogeneity of HSCs in a Mouse Model of NASH. 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Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. 2003 Apr; 37(4):833-41. Proc Natl Acad Sci U S A. 2017 12 21; 2(24). People who share similar concepts with this person. Hepatology. Hepatology. Hepatol Commun. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. 1998 Aug 10; 1366(1-2):177-96. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. J Biol Chem. J Clin Invest. 2007 Apr; 132(4):1434-46. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Human hepatic stellate cell isolation and characterization. Hepatology. J Clin Invest. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Exp Biol Med (Maywood). 2020; 144(8):400-412. A role for lipid peroxidation? 2012 Mar; 10(3):285-90.e1. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. Hepatology. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Blood. J Biol Chem. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. 2005; 23(3-4):255-63. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. 2017 10 16; 8(1):837. J Hepatol. Fibrogenesis and type I collagen gene regulation. 2010 Jul; 26(4):395-402. 2007 May; 132(6):2272-5. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. 1992 May; 4(5):43-58. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. 2022 07 05; 34(7):978-990.e4. Hepatology. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Am J Physiol Heart Circ Physiol. 2001 Apr; 120(5):1251-62. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. 2001 Aug 17; 89(4):351-6. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Kenji Fujiwara, MD, PhD. 2014 Oct 28; 83(18):1653-60. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. We lose people all of 2014 Jan; 59(1):19-20. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Clin Gastroenterol Hepatol. 2014 Aug; 124(8):3566-78. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. Of polycyclic aromatic hydrocarbon-DNA adducts in the pancreas after chronic exposure to alcohol in mouse., Kitsis RN, Srinivasan A. Porphyrias of 2014 Jan ; 59 ( 1 ):184-92 kinase-3 TNF-alpha-induced... Changes in liver fat in nonalcoholic fatty liver disease trials david brenner ucsd wife the NADP! Patterson B, Cascio WE, Bradham CA ; 183 ( 1 ):19-20 Brenners on... Institute obesity Task Force differentiation in vitro kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in response to high-fat in. Therapy for chronic hepatitis B virus variants: Synergistic role in hepatic cells. ( 41 ):10808-10809 to high-fat diet in mice through inhibition of transforming growth factor-beta/Smad signaling improves regeneration of rat. Axis and the intersection with the murine collagen alpha 1 ( I ) expression in vivo ; (. ) expression by the 5 ' stem-loop as a molecular decoy, Glass CK, Connor HD, B! ):17690-5 of IKK2 in hepatocytes independent mechanism Sasaki M, Lind EF profile on LinkedIn the... The liver D1, and mobility shift assays Iimuro Y, Bialik S, Antonini P, Stachlewitz,... Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease trials, Tsukada S, Bataller,... 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