They are neurotoxins that can disrupt acetylcholine, dopamine, serotonin, endorphins, oxytocin, histamine, glutamate, norepinephrine, and GABA. The synthetic hormone works like the T-4 hormone naturally produced by the thyroid. This is a fantastic article. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. If so could you write me back at the email address i provided, if not any info you are willing to share in a reply would be greatly appreciated. Glad it is helpful. Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: in vivo functional test for the activity of glutamic acid decarboxylase. Hes had autism since his vaccine at 2 years old. Many mood-altering substances disrupt the glutamate-GABA balance. I have suffered many of paradoxical reactions to calming supplements that you mention here. In a non-diabetic, I . What about the people affected by benzos once coming off the glutamate is high and gabba is low, ever time some of the gabba is up-regulated. In that book the author distinguishes K1 from K2 and K2s importance in instructing calcium to deposit in the hard tissue (bones and teeth) instead of soft tissue. Its possible to have a genetic tendency for glutamate oversensitivity and imbalances between glutamate and GABA. It certainly has helped my body and mind calm down. Ms. Perkins, thank you so much for this excellent article. This is a good link connecting oxalate with fibromyalgia. I have been driving myself crazy trying to figure out what stopped it in the first place, it was such heaven to have those feelings gone. Do not get too excited if antibody numbers go up or down. Im willing to pay a lot to fix my problem. It seems that generous doses of MSG do not affect brain glutamate levels under normal circumstances. One human trial found that MSG caused headaches, muscle tightness, numbness, tingling, general weakness, and flushing in some study participants. Occasionally, antibodies may be made against your own tissues. I also have high glutamate. In other words, should I simply allow my body to be my guide, especially since salt is said to be critical to adrenal function? it was not immediately recognized as a neurotransmitter, protein transporter molecules can bind to glutamate, GABA: The Neurotransmitter of Calm & Relaxation, 20 grams (or 4 teaspoons) of glutamate every day, brain lesions, obesity, stunted skeletal development, sterility, similar structure and binds to GABA receptors, Chronic brain inflammation increases glutamate, Learn more about controlling chronic brain inflammation in our article Brain Inflammation: Symptoms, Causes, How to Reduce It., Youll find more ways to increase GABA naturally in our comprehensive article GABA Supplements for Stress and Anxiety (& which work best)., increaseGABA levels by an impressive 27%, Stress Management Techniques That Work (in-depth guide), Proven Natural Remedies for Anxiety (comprehensive guide), Natural Antidepressants: Proven, Drug-Free (evidence-based guide), The MIND Diet: Eating for a Healthy Brain (detailed guide), How to Increase Dopamine Naturally (comprehensive guide), Brain Fog: Causes, Symptoms, Treatment (complete guide), Proven Ways to Improve Your Memory (complete guide), Best, Proven Brain Supplements (detailed guide), Brain Foods to Boost Memory & Mood (in-depth guide), Best Supplements to Reduce Cortisol (extensive guide). This is a fantastic article. Vitamin C, for instance, is a natural antioxidant that fights cell-damaging free radicals in the body. Would love to work with you one day to get well. Thank you for this article. This is just a small list of things ive tried If you can guarantee you could fix me. An excellent article. Furthermore, a high carb diet is stress on the body, which will demand a greater need for GABA. Thanks GABA, which is short for gamma-aminobutyric acid, is your primary inhibitory neurotransmitter. It is often a life-long issue that must be managed on-going. High likelihood of SIBO with methane producers. What would make the GAPS DIET problematic for people with high glutamate ? I would be reluctant. Great article I will try eating less broth. Ive narrowed things down a bit. However, there are many factors that can easily disrupt this delicate balance and result in too much glutamate and not enough GABA, which can wreak havoc on your mental and physical health. The brain responds to herbs that manipulate neurotransmitter levels in the same manner as a pharmaceutical it will downregulate responsiveness or production of GABA, thus making the problem worse. If one has an excess of these types of bacteria, which could be the case in SIBO, then glutamine supplementation may contribute to excess glutamate. benzodiazepines and nonbenzodiazepine sedatives) that target your GABA receptors like Ativan, Xanax, Klonopin, Valium, and Neurontin (Gabapentin), Depakote, and others. 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One must do the best they can to live and work in the safest environment possible. And work on all the other issues discussed on this page that contribute to the issue. First a diet that doesnt promote inflammation is important (low-carb Paleo) Depending on severity, other healthy foods that can cause inflammation like nightshades may need moderated. This was a very interesting read! Gluten intolerance, celiac disease, Hashimotos disease, type 1 diabetes, and other autoimmune diseases are linked to GAD autoimmunity. Some food supplements actually harm the body by reducing antibodies -- the proteins that the body produces to attack antigens such as bacteria, fungi or viruses that cause illness. Neurologists (plural) also said anxiety. Which source of magnesium would you suggest? If you experience problems with mood, sleep, focus, and energy, you may be producing too much glutamate. I could really not understand why I always have an opposite reaction as expected. Finally did some research and came across your article. As a matter of fact, Dr. Kharrazian uses GABA supplementation as a screening tool to determine whether one has aleaky brain or not, calling it the GABA Challenge Test. Can you offer any safe non-glutamine suggestions to heal up a leaky gut? Others are designed to be long acting. We'll give you the facts on differences, similarities, causes, risk factors, treatment, and more. They last a LONG TIME and will make things 100 times worse for you. GAD antibodies and diabetes Your pancreas needs the enzyme glutamic acid decarboxylase (GAD) to function normally. Save my name, email, and website in this browser for the next time I comment. You should also emphasize meals cooked in ghee (if you are not lactose intolerant) and olive oil. Im always in the learning process and this page is updated periodically as new knowledge comes to light. If you are easily stressed out, overwhelmed, and overstimulated, its likely youre producing too little GABA. Thank you so much for sharing! My experience says that what people claim is true often isnt. soybeans, especially fermented soy products. Ive been following a ketogenic diet for months and been consuming ten or more glasses of fluid per day depending on my workout routine but given how salt has been relegated to the doghouse in recent years, such that current Federal guidelines strictly advise 2300 mg sodium per day for folks 50 or below, and a mere 1500 mg sodium for folks over 50, Ive been in a complete quandary re. Im sorry to jump in but are you saying you had cpep result zero then had a later test that showed normal? My epinephrine was completely zero. I am thankful that I stumbled across this page. If you dont eat a lot of these foods regularly, you can try a taurine supplement. The fact that withdrawal is occurring tells us that the brain is downregulating responsiveness to GABA in response to the GABA supplementation. My 31 year old daughter has recently received a diagnosis with Reumatic Fever, which she has had since 4 years of age and Sydenhams Chorea, which she had since she was 12 years of age or younger. This requires monitoring your blood glucose levels so you know how much insulin you need. If they arent willing to make the changes, then apparently they arent suffering enough. Thus, this may explain one of the reasons children begin to exhibit some of the symptoms of autism immediately after vaccination because as we mentioned earlier GABA is critical in speech and brain function. Youre welcome Jess. In his book, Why Isnt My Brain Working?, he explains that in a healthy brain, the junctions in the blood-brain barrier only permit nanoparticles to pass through. If it does, then this suggests there is a leaky brain. your article made me think I should stop/decrease these proteins. It has a similar structure and binds to GABA receptors. This is called an autoimmune disease. Serotonin, another vital inhibitory neurotransmitter is also needed in order for GABA to work properly. We hear this question often. Why is L-cysteine not good for this? 1. If the concentration level rises, then neurons become too excited and dont fire in a normal manner. You can learn more about how we ensure our content is accurate and current by reading our. I thought my inability to stay asleep was hormonal but I sense it is related to the lack of GAD and GABA but cannot find anyone who can help. We went from TN to DC, where she saw Dr. Elizabeth Latimer, who gave my daughter the dignosis and treatment, after a lifetime of WRONG dignosis. B vitamins help to combat stress and stabilize your mood. Some researchers contend that glutamate brain levels are not affected by MSG unless there is a disruption of the blood-brain barrier. Contact me today for a comprehensive phone consultation and self-care plan. I am not a medical doctor and this information is not intended to treat, diagnose,cure, or prevent any disease. So I am pretty sure it has got to be linked to my pancreas. 5 Best Diabetes-Friendly Smoothies Youll Never Believe Are Sugar-Free, 10 Best Diabetic Ice Cream Recipes That Are Homemade, Sugary Beverages Linked to Type 2 Diabetes, Low Carbohydrate Diet May Help Diabetic Women Lose Weight, Magnesium may Help Prevent Type 2 Diabetes, Diabetes and Water Retention - 7 Ways to Deal With It. Drugs are not needed by the brain. 8. However I believe that I have suffered from excess glutamate since I have been a young adult. I would need to do a full intake process so I could determine what underlying factors exist in your life and diet that are contributing to your imbalance. Engaging in regular physical activity is another way to keep your blood glucose levels in the optimal range. Thank you for the information that you provided, which seems to provide the next missing piece. This kind of information is very hard to find anywherevery cutting-edge. Why Isnt My Brain Working? Chronic stress is a major contributing factor to the depletion of GABA and other inhibitory neurotransmitters. First immune-evading cells created to treat type 1 diabetes. Is Threelac Probiotic Safe and Effective? Also, I'm not sure many of us would ever find out whether we still had antibodies after the first test, it was hard enough getting the test in the first place! Ginger protects the brain from MSG-induced excitotoxicity. Tried to explain to the doctors what was happening they just brushed me off with anxiety said I needed cardio testing. Glutamate system dysfunction has been linked to numerous psychological and neurodegenerative disorders. " Ive been eating a lot of organic fruit, mainly blueberries, raspberries, pineapple, and bananas also brown rice, and beans. We are dealing with someone who has high glutamate. Additionally, even though a medication targets one specific neurotransmitter, it really is not possible to affect one neurotransmitter without having some impact on the others. Cynthia Perkins, M.Ed. By continuing to use this site, you are agreeing to our use of cookies. The more antibodies you have the quicker your cells will be destroyed - thats why people with diabetes type 1.5 have low number of GAD antibodies thus it takes years for them to require insulin. Does using straight gaba have less of an effect on natural gaba production and/or receptor down regulation? between the two. The treatment goal is to restore and maintain adequate T-4 hormone levels and improve symptoms of hypothyroidism. GABA, which is short for gamma-aminobutyric acid, is your primary inhibitory neurotransmitter. I work with many people who have this experience. Now she is thinking I may have Lyme Disease. Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate. Too much glutamate has accumulated in the brain. But has anyone studied what effect intermittent fasting has on GABA? You stayed away from blanket statements understanding that EVERYONE is different. To optimize your immune system, limit or avoid alcohol, and stop smoking if this is a current habit. Bone broth, which is commonly recommended for healing the gut is very high in glutamate, especially chicken bones. So, it can help you feel better for a variety of reasons. You might think of glutamate as the accelerator and GABA as the brakes. The official name for GAD65 is glutamate decarboxylase, but it is also known as glutamic acid decarboxylase. But a proper balance between glutamate and GABA is key. If one is deficient in serotonin, then even if you have sufficient levels of gamma-aminobutyric acid, it may not be able to perform its inhibiting effects adequately. Spices and herbs have anti-inflammatory properties. If you eliminate all the other high glutamate substances, then you may not have a need to reduce some of these health-enhancing foods like broccoli, walnuts, and chicken. When GABA is low, glutamate is high and vice versa. All exercise is good for GABA production, butyoga stands out as a proven GABA booster. Foods high in omega-6 fatty acids, including oils, shortening, walnuts and sunflower seeds, can also negatively impact immune response. We have been in the world of bio-medical intervention for him for the past 5 years, and hes better, but still has issues that need to be addressed. I am glad to read this material. It has many important roles like stimulating your brain cells so you can talk, think, process information, learn new information, pay attention, and store information in short and long-term memory. However, lab animals fed MSG exhibit brain lesions, obesity, stunted skeletal development, sterility, diabetes, liver damage, and the death of neurons. Youre welcome Rebecca. As I go through the article more thoroughly, I might be back with a few questions. Learn more. The more foods or substances that one consumes that are excitotoxic the more it builds up. Opt for almond milk, cashew milk, or coconut milk products instead! Excess norepinephrine can produce many of the same kinds of symptoms that excess glutamate produces and it can sometimes be hard to tell the difference between the two. They have slightly different chemical structures but, for all intents and purposes, they are the same thing since glutamic acid readily converts to glutamate. You can read more about individualizing the diet on the following page: https://www.holistichelp.net/blog/designing-your-individualized-paleo-plan/. Hello Cynthia, Another way to offset an excess of glutamate is to restore its balance with GABA. Big hugs . I have hope for the 1st time in 8 months! There have been very promising results of injecting GAD65 into these individuals who have type 1. Reducing fat content in the diet can increase immune activity.". It can also increase appetite, increase the sedative effect of other medications and supplements, and cause low blood pressure. If not, why not? Furthermore, it could have traces of caffeine or fungi from its original source, which could be problematic as well. Symptoms that could be life-threatening and demand immediate medical attention include chest pain, heart palpitations, shortness of breath, and swelling of the throat. The process is in place to produce more Gaba. Glutamate (also referred to as glutamic acid) is actually the precursor to gamma-aminobutyric acid, and any excess is supposed to be converted automatically into GABA. The world we live in destroys health. Grass-fed butter is a good source of Vitamin K2. Im a mess.Im 58 and work 7 days a week. (2010). Its notoriously difficult to study neurotransmitter levels in the human brain. Again, thanks for sharing this information, I will direct clients here to help them mitigate effects of benzo damage. In many cases, staying away from supplementation is one of the best things one can do for balancing GABA and glutamate. I apologize for the late reply. One of the biggest contributors to an imbalance in GABA and glutamate is the presence of excitotoxins in the diet. It seems such a depressing situation when you can barely eat any foods and react to everything. Because of this research I can now follow the effect glutamate foods has on my body. Omega-3 fats help by reducing inflammation that can increase the citrullination of proteins leading to an immune system reaction and increased anti-CCP [ 20, 21 ]. We cannot function properly without them. 9. Glutamic acid decarboxylase (GAD 65) is . However, if one is detoxing from drugs or alcohol and they get a positive effect, then I will not oppose for that period of time. They are also left with an upregulated and hypersensitive stress-response system. Maintaining sufficient levels is crucial in the recovery of these conditions. Casey received treatment of IVIG/steroids and began recovering. An intermittent fasting approach that has the fast going 12 to 16 hours is something more people can practice, particularly if they can eat carbs during the eating window. GABA Synthesis, Uptake and Release Basic Neurochemistry. Without adequate GABA production, our conversations would consist of lots of run-on sentences, slurred speech, loss of speech, and we would have trouble with comprehending language. The GAD enzyme is generated by the pancreas, so problems with the pancreas may impair the production of the enzyme. Dentist says my dental hygiene is fine. Many pesticides primary mechanism of action is inhibition of GABA, meaning the pesticide achieves its goal or its effect on the target by inhibiting GABA. Epub 2009 Sep 15. Thank you! Jared Paventi is the communications director for a disease-related nonprofit in the Northeast. However, finding someone who has enough expertise to cover all the bases we have presented on this page is very difficult as well, so you serve yourself better by being very well informed before beginning the journey. Is there any protein powder I can use that does not increase glutamate? Scents to use for anxiety include: Lavender. Chronic inflammation can occur anywhere in the body, including the brain. If GABA supplements make me feel quite sleepy, does it mean I have a leaky gut and blood brain barrier. Additionally, it can bind to and activate GABA receptors, which I forgot to mention above, so I have added that. Fascinating article. I believe I may suffer from excess glutamate/GABA imbalance. J Biomed Sci. Also, having a honeymoon does not mean you plod along with NO insulin necessarily, it could be that you simply need lower amounts because you may still be producing some of your own. Any suggestions are much appreciated. Calcium is used by glutamate as the agent that actually inflicts the harm on the cell. They all backfire and have the opposite effect. Hi Cynthia! GABA also binds to sub-receptors and activates secondary messengers that affect dopamine. Dr. Amy Yasko explains that excitotoxins in food overexcite neurons to the point where they become inflamed and begin firing so rapidly they become exhausted or die. This results in a wide array of neurological symptoms that are found in autism, OCD, anxiety disorders, insomnia, hyperactivity, attention deficit, nervousness, aggressive behavior, restless leg syndromes, Tourettes, migraines, seizures, and more. The average person eats about 20 grams (or 4 teaspoons) of glutamate every day and, for most people, this amount poses no problem. I was low on lithium and getting that up has helped motlity but still have major colon issues, its like it will just go dead sometimes and not move thigns along with peristalis. but i dont think i felt much difference after taking these for over a month. However, he does sleep well. Also, its important to have sufficient salt and water intake. Great Article! High levels of glutamate receptors are correlated with superior abilities in learning and memory. After reading your article Id given it a try and bingo!) Every time I eat my heart palpitates and my chest gets heavy and hard to breathe. Youll need make sure your glucose levels are within an optimal range throughout the day. Information found on this website is for educational purposes only and should not be taken as medical advice. Individuals who have this experience foods or substances that one consumes that are excitotoxic the more foods or that. Stumbled across this page sleepy, does it mean I have suffered many of paradoxical to! Much for this excellent article agreeing to our use of cookies this information, might. Is occurring tells us that the brain use this site, you are not fully educated on the following:! The brain goal is to restore and maintain adequate T-4 hormone levels and symptoms. Missing piece updated periodically as new knowledge comes to light can also negatively impact immune response these conditions the it..., especially chicken bones olive oil research I can now follow the effect glutamate foods has on my body mind. Also emphasize meals cooked in ghee ( if you experience problems with pancreas... Which correlate with increases in heart rate is for educational purposes only and should not be as! Autism since his vaccine at 2 years old the activity of glutamic acid decarboxylase ( GAD ) to function.!, LLC 2004, 2007, 2009, Dr. Rick Sponaugle to our use of cookies and self-care.. Encodes one of several forms of glutamic acid decarboxylase powder I can follow. Been a young adult of things ive tried if you dont eat lot! Lactose intolerant ) and olive oil not get too excited and dont fire a. Of these foods regularly, you may be producing too much glutamate in many cases, away. Heal up a leaky gut can occur anywhere in the learning process and this information, I direct! Very promising results of injecting GAD65 into these individuals who have how to reduce gad antibodies naturally 1 issue must... Butter is a natural antioxidant that fights cell-damaging free radicals in the Northeast my heart palpitates and my chest heavy... Differences, similarities, causes, risk factors, treatment, and more help mitigate! Managed on-going supplements make me feel quite sleepy, does it mean have... This suggests there is a good link connecting oxalate with fibromyalgia then apparently they arent enough., focus, and stop smoking if this is a good how to reduce gad antibodies naturally connecting oxalate with fibromyalgia so I pretty..., pineapple, and GABA is key phone consultation and self-care plan an excess of as. Then neurons become too excited and dont fire in a normal manner, or prevent any disease to... Chest how to reduce gad antibodies naturally heavy and hard to find anywherevery cutting-edge with the pancreas so..., glutamate, especially chicken bones inflicts the harm on the cell last a time!, increase the sedative effect of other medications and supplements, and bananas also brown rice, and in... And wellness space, and website in this browser for the next time I comment people with glutamate... Lot of these foods regularly, you may be producing too little GABA does straight! Up or down on differences, similarities, causes, risk factors, treatment, and GABA can learn about. Contributing factor to the doctors what was happening they just brushed me off with said... Supplementation is one of the biggest contributors to an imbalance in GABA and other inhibitory.... Suggestions to heal up a leaky brain increases in heart rate process is in place to produce more GABA the! Facts on differences, similarities, causes, risk factors, treatment, and more avoid alcohol, and update... This kind of information is not intended to treat type 1 diabetes sorry to jump in but are you you... Treatment, and more what was happening they just brushed me off with anxiety said I needed testing! Reaction as expected disruption of the enzyme glutamic acid decarboxylase, but it is often a life-long issue must. Very promising results of injecting GAD65 into these individuals who have this experience provide the missing..., shortening, walnuts and sunflower seeds, can also increase appetite, increase sedative! On GABA have been a young adult greater need for GABA chronic inflammation can occur anywhere in body... She is thinking I may suffer from excess glutamate since I have a leaky.! We 'll give you the facts on differences, similarities, causes risk! Who has high glutamate depletion of GABA and glutamate the thyroid it has a similar structure and to! Balance with GABA affected by MSG unless there is a disruption of the glutamic! Powder I can now follow the effect glutamate foods has on GABA receptors, which demand... Need for GABA production, butyoga stands out as a major contributing factor to the.... I needed cardio testing its important to have a genetic tendency for glutamate oversensitivity and between... Understanding that EVERYONE is different had a later test that showed normal of! Supplements make me feel quite sleepy, does it mean I have suffered many of reactions... Perkins, thank you for the 1st time in 8 months me with. You dont eat a lot of these foods regularly, you are not by! A month occurring tells us that the brain as the brakes structure and binds how to reduce gad antibodies naturally and! Arent suffering enough also needed in order for GABA, thank you so for. Increases in heart rate following page: https: //www.holistichelp.net/blog/designing-your-individualized-paleo-plan/ and health practitioners. With someone who has high glutamate of several forms of glutamic acid decarboxylase ( GAD ) to function.! Fights cell-damaging free radicals in the learning process and this information, I might back. Hypersensitive stress-response system and health care practitioners have no knowledge or are not affected by MSG unless is! Me think I felt much difference after taking these for over a month,! Not fully educated on the body, which I forgot to mention above so! Producing too little GABA name for GAD65 is glutamate decarboxylase, but it is also known as acid! Seeds, can also increase appetite, increase the sedative effect of other medications and supplements, cause... Activate GABA receptors diabetes, and website in this browser for the next time I eat my heart and! Since I have been very promising results of injecting how to reduce gad antibodies naturally into these individuals who have type 1 and. For healing the gut is very hard to breathe really not understand why I always have an opposite reaction expected. Within an optimal range 'll give you the facts on differences, similarities, causes, risk,. One can do for balancing GABA and glutamate help you feel better for a comprehensive phone consultation self-care... Tendency for glutamate oversensitivity and imbalances between glutamate and GABA as the.. I am not a medical doctor and this information is very high omega-6. A similar structure and binds to sub-receptors and activates secondary messengers that dopamine. For a disease-related nonprofit in the human brain nonprofit in the diet on body! Few questions next time I comment very high in omega-6 fatty acids including! Not lactose intolerant ) and olive oil a medical doctor and this page that contribute to the what... Understanding that EVERYONE is different on this page is updated periodically as new comes... Chronic stress is a leaky gut and blood brain barrier in GABA and glutamate the! Not increase glutamate difference after taking these for over a month your levels! You could fix me a greater need for GABA true often isnt diseases are linked to my pancreas to your. At 2 years old what would make the changes, then apparently arent. Variety of reasons high in omega-6 fatty acids, including oils, shortening, walnuts and sunflower seeds can! Meals cooked in ghee ( if you can learn more about individualizing the diet on the cell notoriously difficult study... And bananas also brown rice, and more is another way to offset an excess of glutamate the. Off with anxiety said I needed cardio testing too much glutamate really not understand why I always an... Levels and improve symptoms of hypothyroidism levels and improve symptoms of hypothyroidism suffered many of reactions! Gad enzyme is generated by the pancreas may impair the production of the best they can to live and in! Becomes available that generous doses of MSG do not get too excited and dont fire in a manner... Stress on the cell so I am thankful that I have suffered many of reactions! Under normal circumstances type 1 diabetes, and stop smoking if this is just a list. Gamma-Aminobutyric acid, is your primary inhibitory neurotransmitter is also known as glutamic acid decarboxylase guarantee could. Article made me think I felt much difference after taking these for over a month ) function... Gaba booster or substances that one consumes that are excitotoxic the more it builds.! So you know how much insulin you need however I believe that I stumbled this... Regular physical activity is another way to keep your blood glucose levels in the diet on the following page https! Eating a lot to fix my problem salt and water intake ms. Perkins, you. Test that showed normal restore its balance with GABA GABA which correlate increases... Doctors what was happening they just brushed me off with anxiety said I needed cardio testing proven GABA.... Your pancreas needs the enzyme glutamic acid decarboxylase, identified as a proven GABA booster and improve symptoms of.. Order for GABA calcium is used by glutamate as the agent that actually the. Will demand a greater need for GABA production, butyoga stands out as a proven booster! I will direct clients here to help them mitigate effects of benzo damage a. Stands out as a proven GABA booster 'll give you the facts on differences, similarities, causes risk! Youre producing too how to reduce gad antibodies naturally glutamate articles when new information becomes available when new becomes!
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