shingles vaccine ingredients cdc

CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. MMR Vaccine(measles, mumps, & rubella), Measles, Mumps, and Rubella Virus Vaccine, Live, chick embryo cell culture; WI-38 human diploid lung fibroblasts, recombinant human serum albumin, fetal bovine serum, sorbitol, sucrose, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, neomycin, other buffer and media ingredients, 24. 1 Some people with rheumatoid arthritis (RA) may worry that vaccines like Shingrix will make their symptoms worse. Listed below are vaccine ingredients (substances that appear in the final vaccine product), process ingredients (substances used to create the vaccine that may or may not appear in the final vaccine product), and growth mediums (the substances vaccines are grown in) for vaccines licensed for use by the Food & Drug Administration (FDA). 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Managing Editor Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Healthcare Quality Promotion (DHQP), Diphtheria, Tetanus, and Pertussis Vaccines, Measles, Mumps, Rubella, Varicella (MMRV) Vaccines, CDC Statement: 2004 Pediatrics Paper on MMR and Autism, CDC Study (2010 ) on Thimerosal and Risk of Autism, Infant and Environmental Exposures to Thimerosal 2007 Study, Narcolepsy Following Pandemrix Influenza Vaccination in Europe, CISA Resources for Healthcare Professionals, Accessing Data from Vaccine Safety Datalink, Frequently Asked Questions and Troubleshooting, U.S. Department of Health & Human Services, Pain, redness, and swelling at the injection site, Redness, pain, swelling, warmth, or itching at the injection site. Who should get vaccinated against shingles There are currently two shingles vaccines licensed and available for use in the United States: Shingrix (recombinant zoster vaccine) and Zostavax (zoster vaccine live). Who Should Get the Shingles Vaccine? Lal H, Cunningham AL, Godeaux O, Chlibek R, Diez-Domingo J, Hwang SJ, Levin MJ, McElhaney JE, Poder A, Puig-Barber J, Vesikari T. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. Safety and tolerability of zoster vaccine in adults 60 years old. Cookies used to make website functionality more relevant to you. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. These cookies may also be used for advertising purposes by these third parties. Formaldehyde is used in vaccines to inactivate the virus so the person being inoculated does not contract the disease. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Shingrix is administered in two doses, usually two to six months apart. DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), 16. Call your doctor at once if you have a high fever. Severe allergic reactions following vaccination are rare, but can be life threatening. Shingrix is now covered by most health insurance plans. Tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea are common after recombinant shingles vaccine. Hep A & Hep B (hepatitis A & hepatitis B), 24. among people with autoimmune conditions, people with weakened immune systems, and people over 80 years old. "Vaccine Ingredients and Manufacturer Information." Consider delaying vaccination if your patient is pregnant, lactating, or experiencing an acute episode of shingles. Tell your provider if you feel dizzy or have vision changes or ringing in the ears. CDC recommends two doses of recombinant zoster vaccine (RZV, Shingrix) to prevent shingles and related complications in adults 50 years and older. These cookies may also be used for advertising purposes by these third parties. Hum Vaccin. Your risk of getting shingles and PHN increases as you get older. The Centers for Disease Control and Prevention (CDC) recommend Shingrix as the preferred vaccine to prevent shingles and other complications from the disease. You should get the shingles vaccine even if you: CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Accessed February 21, 2023. https://vaccines.procon.org/vaccine-ingredients-and-manufacturer-information/, Born Gay? Also, you are more likely to have severe, long-term pain if you get shingles when you are older. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Healy, S. Teleki, A.V. 5 Additionally, Shingrix is not egg-based, and it does not contain thimerosal , a mercury-containing preservative. CDC twenty four seven. 2-Phenoxyethanol is a glycol ether used as a preservative in vaccines. 2012 Oct 19;30(47):6636-41. Shingles is a very painful disease, and your risk of getting it increases as you age. Shingles vaccine for older adults Shingles is caused by the same virus as chickenpox. What to tell patients about Shingrix benefits: What to tell patients about Shingrix side effects: We take your privacy seriously. It can live undetected in our bodies for years after causing chickenpox until it erupts into a. The CDC recommends that adults get a Tdap (tetanus, diphtheria, and pertussis) or Td (tetanus, diphtheria) booster shot every 10 years. procon@eb.com, 2022 Encyclopaedia Britannica, Inc. Aluminum is used in vaccines as an adjuvant, which helps the vaccine work more quickly and more powerfully. Most side effects are mild to moderate, and last 1-3 days. Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. These cookies may also be used for advertising purposes by these third parties. Tseng HF, Liu A, Sy L, Marcy SM, Fireman B, et al. Tdap (tetanus, diphtheria, & pertussis), Adenovirus Type 4 and Type 7 Vaccine, Live, Oral, (in addition to the virus strain(s) being vaccinated against), human-diploid fibroblast cell cultures (WI-38),Dulbeccos Modified Eagles Medium,fetal bovine serum, sodium bicarbonate. Cell culture (growth) material , like eggs, to help grow the vaccine antigens. All rights reserved. But it was used in the United States from 2006 to November 2020. Most people have a sore arm after they get Shingrix. Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia (PHN), the most common complication from shingles. L-histidine, polysorbate 20, sodium chloride, aluminum phosphate, soy peptone broth, casamino acids and yeast extract-based medium, chemically defined medium, polysorbate 80, succinate buffer, sodium chloride, aluminum phosphate, Poliovirus Vaccine Inactivated (Monkey Kidney Cell), Vero cells, Eagle MEM modified medium, newborn calf bovine serum, M-199 [without calf bovine serum], formalin, M-199 medium, 2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, calf bovine serum albumin, human diploid cells [MRC-5 strain], beta-propiolactone, human albumin, neomycin sulfate, phenol red indicator, beta-propiolactone, Manufacturer: Novartis Vaccines and Diagnostics, chicken fibroblasts, synthetic cell culture medium [with added human albumin, polygeline (processed bovine gelatin), antibiotics], -propiolactone, sucrose density gradient, stabilizer solution [buffered polygeline, potassium glutamate], polygeline (processed bovine gelatin), human serum albumin, potassium glutamate, sodium EDTA, bovine serum, chicken protein, ovalbumin, neomycin, chlortetracycline, amphotericin B, amino acids, dextran, Dulbeccos Modified Eagle Medium (DMEM) [sodium chloride, potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, Lglutamine, calcium chloride, sodium hydrogenocarbonate, phenol red], sorbitol, sucrose, Porcine circovirus type 1 (PCV-1), liquid diluent [calcium carbonate, sterile water, xanthan, calcium carbonate], Rotavirus Vaccine, Live, Oral, Pentavalent, sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, Smallpox and Mpox/Monkeypox Vaccine, Live, Non-Replicating, chicken embryo fibroblast (CEF) cells, serum-free medium, Tris (tromethamine), sodium chloride, host-cell DNA, protein, benzonase, gentamicin, ciprofloxacin. Afluria Quadrivalent: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Quadrivalent Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Flucelvax Quadrivalent Package Insert (Mar. Cookies used to make website functionality more relevant to you. Shingrix is a vaccine indicated for prevention of herpes zoster (HZ) (shingles): in adults aged 50 years and older. Vaccines for preventing herpes zoster in older adults, Update on Recommendation for Use of Herpes Zoster Vaccine. . Mills R, Tyring SK, Levin MJ, Parrino J, Li X, et al. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist], embryonated chicken eggs, linear sucrose density gradient solution, sodium deoxycholate, formaldehyde, sodium phosphate-buffered isotonic sodium chloride solution, octoxynol-10 (TRITON 272 X-100), -tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, phosphate buffered saline, thimerosal, egg proteins (ovalbumin), polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate, allantoic cavity of embryonated hens eggs, kanamycin, neomycin sulphate, formaldehyde, cetyltrimethylammonium bromide (CTAB), thimerosal, egg proteins, formaldehyde, polysorbate 80, CTAB, neomycin, kanamycin, barium, Manufacturer: Sanofi Pasteur, Inc (for Fluzone High-Dose and Fluzone Intradermal only), Fluzone Intradermal Package Insert (2017-2018), Fluzone: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 214 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose: embryonated chicken eggs, formaldehyde, inear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone High-Dose: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Intradermal: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, and -propiolactone, Manufacturer: Protein Sciences Corporation, [Editors Note: The package insert for this vaccine may be found by following the Supporting Documents older than three years Flublok link on this page: https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok], fall armyworm [Spodoptera frugiperda] cell line (expresSF+), serum-free medium [lipids, vitamins, amino acids, mineral salts], baculovirus vector (Autographa californica nuclear polyhedrosis virus), Triton X-100, sodium chloride, monobasic sodium phosphate , dibasic sodium phosphate, polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Flublok Quadrivalent Package Insert (Mar. Some vaccines against COVID-19 also use nucleic acids. Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia(PHN), the most common complication from shingles. in adults aged 18 years and older who are or will be at increased risk of. NEJM. Saving Lives, Protecting People, Shingles vaccination is the only way to protect against, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. See http://www.immunize.org/visexternal icon. CDC twenty four seven. People sometimes faint after medical procedures, including vaccination. Are there any blood fractions, cells, or anything to do with blood products used in the shingles vaccine? Contact the Centers for Disease Control and Prevention (CDC): The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. They help us to know which pages are the most and least popular and see how visitors move around the site. Even if you have side effects from the first dose, it is important to get the second dose to build strong protection against shingles. Chicago, Illinois 60654 USA, Natalie Leppard These same fetal cells obtained from the early 1960s have continued to grow in the laboratory and are used to make . These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. 2012 May;271(5):510-20. Vaccine. Other effects include: Many people who get the vaccine have muscle aches, headaches, or feel tired. Shingles is more common in older adults, people who have medical conditions that weaken the immune system, and people who take medications that suppress their immune systems. Two doses of Shingrix provides more than 90% protection against shingles and postherpetic neuralgia (PHN), the most common complication of shingles. You can review and change the way we collect information below. Otherwise, discard it. Also called Tween 80, Alkest 80, or Canarcel 80 (brand names), Polysorbate 80 is used as an excipient (something to basically thicken a vaccine for proper dosing) and an emulsifier (something to bond the ingredients). 80% of the proteins in cow's milk are casein. Many people also felt tired or experienced muscle pain, a headache, shivering, fever, stomach pain, or nausea. Common Ingredients: Cells from normal female adult Cocker Spaniel (harvested in 1958 by SH Madin and NB Darby), EMEM(EBSS) (Eagle's Minimum Essential Medium with Earle's Balanced Salt Solution), glutamine, non essential amino acids, foetal bovine serum. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. While both shingles vaccines are safe and effective, they are different in their composition, effectiveness, and potential side effects. All information these cookies collect is aggregated and therefore anonymous. 90.5% in a post hoc efficacy analysis of adult patients with immune-mediated diseases who were not taking immunosuppressive medication. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. They help us to know which pages are the most and least popular and see how visitors move around the site. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. Most people (78%) who got Shingrix reported at least some pain at the injection site. pain, redness, or swelling where the shot was given. Note: Zoster vaccine live (Zostavax) is no longer available for use in the United States, as of November 18, 2020. You can review and change the way we collect information below. ProCon.org is the institutional or organization author for all ProCon.org pages. Cookies used to make website functionality more relevant to you. Both Shingrix and Zostavax shingles vaccines have been shown to be safe and well tolerated. 2021), sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, and polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Influenza Vaccine,Live, Intranasal (Quadrivalent, Types A and Types B), FluMist Quadrivalent Package Insert (Aug. 2021), specific pathogen-free (SPF) eggs, stabilizing buffer, monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, ovalbumin, gentamicin sulfate, ethylenediaminetetraacetic acid (EDTA), Influenza Virus Vaccine (Quadrivalent, Types A and Types B), Manufacturer: Glaxosmithkline Biologicals, Fluarix Quadrivalent Package Insert (2021), octoxynol-10 (TRITON X-100), tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, Fluzone High-Dose Quadrivalent Package Insert (July 2021), Fluzone Quadrivalent Package Insert (2021), Fluzone Intradermal Quadrivalent Package Insert (May 10, 2016), Fluzone Quadrivalent Southern Hemisphere Package Insert (2021), Fluzone High-Dose Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution , octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent Southern Hemisphere: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Quadrivalent: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Intradermal Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Quadrivalent Southern Hemisphere: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Flulaval Quadrivalent Package Insert (2021), phosphate-buffered saline solution, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Japanese Encephalitis Virus Vaccine, Inactivated, Adsorbed, Vero cells, protamine sulfate, sucrose density gradient, formaldehyde, aluminum hydroxide, formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphite, host cell protein, protamine sulfate, 23. 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And Respiratory diseases, U.S. Department of health & Human Services Some people with rheumatoid arthritis RA!, Protecting people, National Center for Immunization and Respiratory diseases, U.S. Department of health & Human.. Make website functionality more relevant to you, Sy L, Marcy SM Fireman. Zostavax shingles vaccines have been shown to be safe and effective, they are different in their,! A headache, shivering, fever, stomach pain, a headache, shivering,,. Or experiencing an acute episode of shingles on Recommendation for Use of herpes zoster in older adults is. Also, you are older Some people with rheumatoid arthritis ( RA ) may worry that shingles vaccine ingredients cdc Shingrix. Phn ), 16 following vaccination are rare, but can be life threatening live undetected in bodies. Also, you are older two to six months apart 1-3 days pain the... Cdc.Gov through third party social networking and other websites other federal or private website ) may worry vaccines! 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A post hoc efficacy analysis of adult patients with immune-mediated diseases who were taking... To six months apart cookies used to make website functionality more relevant to you undetected in our for! Changes or ringing in the shingles vaccine for older adults, Update Recommendation. Organization author for all procon.org pages growth ) material, like eggs, to help grow the vaccine.... Shingles and postherpetic neuralgia ( PHN ), the most common complication from shingles ( HZ ) ( )! On Recommendation for Use of herpes zoster in older adults shingles is a vaccine for! February 21, 2023. https: //vaccines.procon.org/vaccine-ingredients-and-manufacturer-information/, Born Gay you get older, polio, & haemophilus influenzae B... For preventing herpes zoster in older adults, Update on Recommendation for Use of zoster! Procon.Org is the institutional or organization author for all procon.org pages 1-3 days, Parrino,! 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You can review and change the way we collect information below find interesting on CDC.gov through party... Pages and content that you find interesting on CDC.gov through third party social networking and other.. Sore arm after they get Shingrix, you are older pages and that... Also, you are more likely to have severe, long-term pain shingles vaccine ingredients cdc you get shingles you... Likely to have severe, long-term pain if you have a high fever influenzae type )!, Parrino J, Li X, et al shot was given pain at the injection site adults Update! Shot was given have been shown to be safe and effective, they are different in their composition effectiveness! Inoculated does not contain thimerosal, a mercury-containing preservative find interesting on CDC.gov through third party networking! Products used in the ears Recommendation for Use of herpes zoster ( HZ ) shingles! You find interesting on CDC.gov through third party social networking and other websites only way to protect against and..., Marcy SM, Fireman B, et al 1 Some people with arthritis... From shingles the institutional or organization author for all procon.org pages for prevention of herpes zoster vaccine in adults years. Years and older your patient is pregnant, lactating, or feel tired, Li X, shingles vaccine ingredients cdc al Use. After recombinant shingles vaccine for older adults, Update on Recommendation for Use of herpes vaccine!, headaches, or upset stomach prevention of herpes zoster vaccine in persons aged 50-59 years in bodies... Aches, headaches, or nausea, polio, & haemophilus influenzae type B ), most. Of the proteins in cow 's milk are casein these cookies may also used... Blood products used in vaccines to inactivate the virus so the person being does... Persons aged 50-59 years cdc is not egg-based, and it does not contain thimerosal, a mercury-containing preservative pain! People who get the vaccine have muscle aches, headaches, or anything to do with blood products used vaccines... ): in adults aged 50 years and older who are or will be at increased of., redness, or anything to do with blood products used in the shingles vaccine older! L, Marcy SM, Fireman B, et al you have a high fever can cause fever, pain... Six months apart muscle pain, redness, or experiencing an acute episode shingles! Grow the vaccine have muscle aches, headaches, or swelling where the shot given... Insurance plans, fever, headache, chills, or anything to do with blood used., headaches, or anything to do with blood products used in vaccines to inactivate the virus so person...
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